The POSEIDON (Patient Oriented Strategies Encompassing IndividualizeD Oocyte Number) group was created in 2015, envisaging discussing and elaborating practical solutions about the diagnosis and management of Low Prognosis Patients (LPP) undergoing Assisted Reproductive Technology (ART).

The group comprises opinion leaders in reproductive medicine from many countries. Its name also reflects the place chosen by its godfather Prof. Alviggi for its first meeting on the Italian island of Ischia.

Five Reasons to use the Poseidon stratification system and its new marker of successful outcome

POSEIDON combines quality and quantity for the stratification of patients with confirmed or expected inappropriate ovarian response to gonadotropin stimulation.

POSEIDON allows clinicians to estimate the number of oocytes needed to achieve its proposed new marker of successful outcome, namely, “at least ONE euploid embryo for transfer in each patient”.

Adopting POSEIDON, clinicians will be able to set patient expectations and establish a workable plan to reduce the Time-to-Pregnancy.

POSEIDON concept of low prognosis helps to improve the management of patients undergoing ART by promoting a tailored therapeutic approach.

POSEIDON concept contributes to identifying more homogeneous populations for clinical trials, thereby providing better tools with which to maximize IVF success rates.

For Professionals


The POSEIDON group has introduced a new stratification system for classifying infertility patients with confirmed or expected low ovarian response to exogenous gonadotropins. Specifically, four subgroup categories have been created based on quantitative and qualitative parameters, namely, i. The age of the patient and the expected aneuploidy rate; ii. Ovarian biomarkers (i.e. AFC and AMH), and iii. The ovarian response of the patient provided a previous cycle of stimulation had been carried out. In the latter, a ‘suboptimal response’ was defined as the retrieval of four to nine oocytes despite adequate pre-stimulation ovarian parameters, as it is associated at any given age with a significantly lower live birth rate compared with normal responders, i.e., those with 10–15 oocytes. And a ‘poor response’ was defined as the retrieval of fewer than four oocytes despite adequate pre-stimulation ovarian parameters.


The management of patients with impaired ovarian reserve or poor ovarian response (POR) to exogenous gonadotropin stimulation has challenged reproductive specialists for a long time. Apart from our limited understanding of its pathophysiology, there is extensive heterogeneity in the definition of the poor responder patient as well as overall disappointing outcomes in assisted reproductive technology (ART) cycles.


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